years experience in photon counting !
Founded in 1993, Becker
& Hickl have introduced a proprietary time-correlated single-photon
counting principle that made TCSPC more than 100 times faster than the
existing devices. Moreover, bh introduced a multi-dimensional TCSPC
process that records the photons not only versus the time in the signal
period, but also versus other parameters, such as experiment time,
wavelength, or spatial coordinates. The bh devices are designed to
record multi-dimensional photon distributions, time-resolved images,
sequences of photon distributions, or multi-dimensional time-tag data.
The bh TCSPC products are complemented by bh picosecond diode lasers,
detector modules, multi-spectral detector assemblies, and experiment
control modules. Based on these components Becker & Hickl supply their
own confocal fluorescence lifetime laser scanning microscope and FLIM
upgrade kits for laser scanning microscopes of various manufacturers.
Moreover, bh is supplier of TCSPC modules for commercial time-domain
optical tomography instruments. bh market activities include currently 5
workshops around the world and distribution of more than 1200 pages of
of multidimensional TCSPC. Introduction of fast TAC/ADC conversion. TCSPC
becomes 100 times faster than it was before. SPC-300 modules with 32 or 128
simultaneously recording detector channels. Time channel width 820 fs.
Saturated count rate 3 MHz.
SPC-330 modules. Improved IRF width.
Routers for parallel operation of detectors.
SPC-430 modules. Continuous Flow mode for
infinite sequential recording. Saturated count rate 8 MHz. First
single-molecule applications. Resolution of bursts, lifetime analysis within
SPC-535 modules. First implementation of TCSPC
FLIM. First FLIM applications.
PMS-300 gated photon counter and multichannel scaler
SPC-630 modules. Introduction of PCI bus. Modules contain time-tag mode,
standard photon distribution modes, and continuous flow mode. PMH-100
detector module simplifies system setup.
SPC-730 modules. Introduction of TCSPC FLIM. Scan Sync In and Scan Sync out
mode. First applications in FLIM microscopy. MSA-300 multichannel scaler.
100 MHz count rate, 5 ns channel width.
SPC-134 four-channel packages for optical
tomography. Devices contain continuous flow mode, standard photon
distribution modes, and time-tag mode. Saturated sustained count rate 32
SPC-130 TCSPC board for industrial applications.
FLIM upgrade kits for Zeiss LSM 510 NLO
SPCImage FLIM data analysis software.
MSA-1000 multichannel scaler. 1 ns resolution, count rate 1000 MHz.
BHL-600 red and NIR picosecond diode lasers.
New SPCM software introduces autosave, auto-accumulate, and automatic page
SPC-830 modules. Fast DMA bus interface.
Saturated sustained count rate 8 MHz. Standard photon distribution modes,
FLIM modes, time-tag recording. For the first time, FLIM and single-molecule
techniques were combined in one instrument.
DCC-100 detector controller solves the problem of detector overload.
PMC-100 cooled detector modules. Internal preamplifier, internal
high-voltage generator, overload shutdown. System setup is greatly
Detector-Shutter modules for non-descanned ports of multiphoton microscopes.
FLIM systems for Leica, Olympus, and Biorad
laser scanning microscopes.
First multi-spectral FLIM
BHLP-700 NIR picosecond diode lasers. Up to 10 mW at 785 nm.
BDL-405 UV picosecond diode lasers.
DDG-100 pulse generator for multiplexed operation of lasers and SPC modules.
First demonstration of double-exponential FRET imaging.
SPC-144 four-channel TCSPC Imaging Package.
Saturated sustained count rate 40 MHz.
BDL-375, 440, and 473 picosecond diode lasers
PML-16 multi-wavelength detector
Online FCS, PCH, and MCS trace calculation in the time-tag mode of the bh
Simple-Tau 140 and Simple-Tau 830 compact TCSPC
MW-FLIM, first multi-spectral NDD FLIM systems for multiphoton microscopes.
Macro-time synchronisation of several TCSPC modules. First full correlation
down to the picosecond region.
PML-16 sixteen channel detector. Internal high-voltage generator, overload
shutdown, control via DCC-100.
High-efficiency single-mode fibre coupling of BDL picosecond diode lasers
FLIM upgrade kits for confocal laser scanning microscopes based on bh BDL-SM
lasers and bh TCSPC technology.
W. Becker, Advanced Time-Correlated Single Photon Counting Techniques
published by Springer.
First edition of BH TCSPC Handbook. 360 pages, 364 references.
CW mode for BDL-SMC picosecond diode lasers.
Second edition of bh TCSPC Handbook. 387 pages, 387 references.
DCS-120 confocal laser scanning systems.
Complete fluorescence-lifetime laser scanning microscopes.
DPC-230 16 channel photon correlator, 160 ps resolution.
SPC-154 package and SPC-150 modules. Standard photon distribution modes,
continuous flow mode, TCSPC imaging, continuous-flow imaging, imaging in the
time-tag mode. Imaging in time-tag mode for SPC-140 and SPC-830.
2008 FLIM systems for Zeiss LSM 710
microscopes. NDD FLIM systems for Leica SP2 MP and SP5 MP
microscopes. Simple-Tau 152 and -154 two and four channel TCSPC
systems. 3rd edition of bh TCSPC Handbook.
2009 GaAsP hybrid detectors. 8-channel
parallel TCSPC and TCSPC FLIM systems
2010 Eight-channel SPAD detector. GaAsP
hybrid detectors in all bh FLIM systems. Z stack FLIM. 4th edition
of bh TCSPC Handbook.
2011 Phosphorescence decay imaging in
DCS-120 and Zeiss LSM 710 FLIM systems. Fluorescence
Lifetime-Transient Scanning (FLITS) DCS-120 Wideband, DCS-120
Multiphoton, and DCS-120 Macro FLIM systems.
2012 DCS-120 electronic alignment,
NIR FLIM, FLITS integrated in DCS-120 and LSM 710 FLIM systems, 5th
edition of bh TCSPC Handbook.
20 th anniversary of Becker & Hickl
MW-FLIM and PML-16 GaAsP multi-wavelength detectors, SPC-150N
TCSPC module, Megapixel FLIM, Mosaic FLIM, BDL-SMN series and
BDS series picosecond diode lasers. Single-molecule burst analysis
Design, Manufacturing and Quality Management
flow from design into manufacturing
Hybrid-circuit, FPGA and
Thin film and thick film hybrid circuits
Automatic placement of
Automatic chip bonding